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Merck

PHR1307

Captopril

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

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A propos de cet article

Formule empirique (notation de Hill) :
C9H15NO3S
Numéro CAS:
62571-86-2
Poids moléculaire :
217.29
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823294
EC Number:
263-607-1
Beilstein/REAXYS Number:
477887
MDL number:
MFCD00168073

Principaux documents

Voir toute la documentation
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InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C0430000, traceable to USP 1091200

API family

captopril

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

104-108 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ACE(1636)

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Captopril acts by inhibiting the angiotensin-converting enzyme and is known as an antihypertensive agent. It finds wide use in the treatment of congestive heart failure.

Application

Captopril may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0067 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Muta. 2 - Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
Parham H and Zargar B
Talanta, 65(3), 776-780 (2005)
Determination of captopril and its degradation products by capillary electrophoresis
Hillaert S and Van den Bossche W
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 65-73 (1999)
Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations
Rahman N, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(6-7), 569-574 (2005)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)
Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro PRDS, et al.
Ecletica Quimica , 28(1), 39-44 (2003)
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