PHR1309
Dimethyl Sulfoxide
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
Sulfoxide, DMSO
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[S](=O)(C)C
InChI key
IAZDPXIOMUYVGZ-UHFFFAOYSA-N
InChI
1S/C2H6OS/c1-4(2)3/h1-2H3
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. D2050000, traceable to USP 1211006
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
General description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Dimethyl Sulfoxide (DMSO) is an amphipathic molecule and contains both highly polar and apolar groups, making it an efficient solvent as it can dissolve in both aqueous and organic solvents. It has its therapeutic use in the treatment of a variety of human conditions such as brain edema, amyloidosis, interstitial cystitis, and schizophrenia. It is a commonly used solvent for hydrophobic pharmaceutical agents, exhibiting effective hydroxyl radical scavenging ability. Commercially it is produced by oxidation of dimethylsulfide (DMS) with dinitrogen tetroxide. It is a component of a wide variety of foodstuffs and beverages.
Dimethyl Sulfoxide (DMSO) is an amphipathic molecule and contains both highly polar and apolar groups, making it an efficient solvent as it can dissolve in both aqueous and organic solvents. It has its therapeutic use in the treatment of a variety of human conditions such as brain edema, amyloidosis, interstitial cystitis, and schizophrenia. It is a commonly used solvent for hydrophobic pharmaceutical agents, exhibiting effective hydroxyl radical scavenging ability. Commercially it is produced by oxidation of dimethylsulfide (DMS) with dinitrogen tetroxide. It is a component of a wide variety of foodstuffs and beverages.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0526 in the slot below. This is an example certificate only and may not be the lot that you receive.
Classe de stockage
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
Certificats d'analyse (COA)
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Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils
Phillis JW, et al.
Neuroscience Letters, 244(2), 109-111 (1998)
Farhana Musarrat et al.
Journal of medical virology, 92(10), 2087-2095 (2020-05-07)
Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is the causative agent of the coronavirus disease-2019 (COVID-19) pandemic. Coronaviruses enter cells via fusion of the viral envelope with the plasma membrane and/or via fusion of the viral envelope with endosomal membranes
Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations.
Kanaze FI, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33(2), 243-249 (2003)
A rapid permethylation of glycolipid, and polysaccharide catalyzed by methylsulfinyl carbanion in dimethyl sulfoxide
HAKOMORI S
Journal of Biochemistry, 55(2), 205-208 (1964)
Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography
Liu F and Jiang Y
Journal of Chromatography A, 1167(1), 116-119 (2007)
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