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Merck

PHR1418

Acide succinique

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Acide butanedioïque

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A propos de cet article

Formule linéaire :
HOOCCH2CH2COOH
Numéro CAS:
110-15-6
Poids moléculaire :
118.09
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823388
EC Number:
203-740-4
Beilstein/REAXYS Number:
1754069
MDL number:
MFCD00002789

Principaux documents

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InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

SMILES string

OC(=O)CCC(O)=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1623411

API family

succinic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

235 °C (lit.)

Quality Level

300

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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Catégories apparentées

General description

Succinic acid is a dicarboxylic acid, which is used primarily as an acidity regulator in the food and beverage industry. Pharmaceutically, it is usually used as a conjugate feeder acid to form succinate salt and as an excipient.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Succinic acid may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2952 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples
Zaky AS
J. Food Compos. Anal., 56(1-2), 25-33 (2017)
Determination of lactic, acetic, succinic, and citric acids in table olives by HPLC/UV
Cunha SC, et al.
Journal of Liquid Chromatography and Related Technologies, 24(7), 1029-1038 (2001)
Optimization and validation of an HPLC-photodiode array detector method for determination of organic acids in vinegar
Zong Y, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 98(2), 422-430 (2015)
Simultaneous HPLC determination of organic acids, sugars and alcohols
Doyon G
Can. Inst. Food Sci Technol. J., 24(1-2), 87-94 (1991)
Improving pharmacy students' understanding and long-term retention of acid-base chemistry
Roche VF
American journal of pharmaceutical education, 71(6), 122-122 (2007)
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