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Merck

PHR1446

Ramipril

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

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A propos de cet article

Formule empirique (notation de Hill) :
C23H32N2O5
Numéro CAS:
87333-19-5
Poids moléculaire :
416.51
NACRES:
NA.24
PubChem Substance ID:
329822606
UNSPSC Code:
41116107
MDL number:
MFCD00865775

Principaux documents

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InChI

1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1

SMILES string

O=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3

InChI key

HDACQVRGBOVJII-JBDAPHQKSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. R0145000, traceable to USP 1598303

API family

ramipril

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... ACE(1636)

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ramipril is an angiotensin-converting-enzyme (ACE) inhibitor, which acts on the renin angiotensin aldosterone system. It is widely used in reducing hypertension by the suppression of the effects of angiotensin II at its receptor, thereby blocking the renin-angiotensin system.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ramipril may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and high-performance liquid chromatography technique.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3757 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

A validated HPLC method for analysis of atorvastatin calcium, ramipril and aspirin as the bulk drug and in combined capsule dosage Forms
Patole MS, et al.
International Journal of Pharmaceutical Sciences Review and Research, 4(3), 40-45 (2010)
A Spectrophotometric method for the determination of ramipril in solid dosage forms
Afleroho EO, et al.
Tropical Journal of Pharmaceutical Research, 11(2), 275-279 (2012)
Development and validation of simultaneous HPLC method for estimation of telmisartan and ramipril in pharmaceutical formulations
Jawla S, et al.
International Journal of PharmTech Research, 2(2), 1625-1633 (2010)
Simultaneous determination of ramipril, hydrochlorothizide and telmisartan by spectrophotometry
Bankey S, et al.
International Journal of ChemTech Research, 1(2), 183-188 (2009)
Tushar A Premchandani et al.
Acta poloniae pharmaceutica, 71(1), 95-106 (2014-05-02)
The present work attempts to formulate and evaluate hollow microcapsules of an antihypertensive drug--ramipril, which will remain in vicinity of absorption site. The emulsion diffusion solvent evaporation method was employed for preparation of microspheres using Eudragit E100. Glycerol monostearate and
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