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Merck

PHR1573

Phenformin Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Phenformin hydrochloride, N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride, Phenethylbiguanide

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A propos de cet article

Formule empirique (notation de Hill) :
C10H15N5 · HCl
Numéro CAS:
834-28-6
Poids moléculaire :
241.72
NACRES:
NA.24
PubChem Substance ID:
329823481
UNSPSC Code:
41116107
EC Number:
212-637-3
MDL number:
MFCD00035039

Principaux documents

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InChI key

YSUCWSWKRIOILX-UHFFFAOYSA-N

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

SMILES string

Cl.NC(=N)NC(=N)NCCc1ccccc1

grade

certified reference material, pharmaceutical secondary standard

API family

phenformin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Phenformin Hydrochloride is the hydrochloride salt of phenformin, which belongs to the second chemical class of oral hypoglycemic agents such as biguanides.

Application

Phenformin Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using surface enhanced Raman spectroscopy technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7788 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Direct spectrophotometric analysis of glipizide and phenformin hydrochloride in pharmaceutical dosage forms
Phalke.NP, et al.
Indian Journal of Pharmaceutical Sciences, 59(1), 18-18 (1997)
Principles of Endocrine Pharmacology, 59(1), 18-18 (2012)
Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering
Zhang Y, et al.
Analytical Sciences, 29(10), 985-990 (2013)
Benjamin D Stein et al.
Journal of proteome research, 18(10), 3703-3714 (2019-08-10)
Recent advances in genome editing technologies have enabled the insertion of epitope tags at endogenous loci with relative efficiency. We describe an approach for investigation of protein interaction dynamics of the AMP-activated kinase complex AMPK using a catalytic subunit AMPKα2
Seon-Hyeong Lee et al.
Cancers, 12(6) (2020-06-03)
Lung adenocarcinoma cells express high levels of ALDH1L1, an enzyme of the one-carbon pathway that catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate and NAD(P)H. In this study, we evaluated the potential of ALDH1L1 as a therapeutic target by deleting the
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