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Merck

62962

L-α-Lysophosphatidylcholine

egg yolk, ≥99.0% (TLC)

Synonyme(s) :

3-sn-Lysophosphatidylcholine, L-α-Lysolecithin

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A propos de cet article

UNSPSC Code:
51321705
NACRES:
NA.25
MDL number:
MFCD00131444

Principaux documents

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biological source

egg yolk

description

zwitterionic

assay

≥99.0% (TLC)

form

powder or solid

composition

16:0, ~69% (fatty acid), 18:0, ~27% (fatty acid), 18:1, ~3% (fatty acid)

solubility

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

wet ice

storage temp.

−20°C

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Catégories apparentées

Application


  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

Biochem/physiol Actions

3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .

Other Notes

Preparation of demembranated frog sperm chromatin

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL4995
BCCL2627
BCCL4996
BCCJ6415
BCCH4112

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Consulter la Bibliothèque de documents

Priscila M Hiraiwa et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(7), 727-736 (2018-08-18)
Trypanosomatid parasites are causative agents of neglected human diseases. Their lineage diverged early from the common eukaryotic ancestor, and they evolved singular mechanisms of gene expression that are crucial for their survival. Studies on unusual and essential molecular pathways lead
Fengfeng Lu et al.
Neuroscience bulletin, 35(3), 434-446 (2019-01-27)
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group
Harvey T McMahon et al.
Nature, 438(7068), 590-596 (2005-12-02)
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization
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