RAB0010
Angiotensin II EIA Kit
for serum, plasma, culture supernatant and cell lysates
Synonyme(s) :
Angiotensinogen, Serpin A8
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A propos de cet article
NACRES:
NA.32
UNSPSC Code:
12352204
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Laissez-nous vous aiderNom du produit
Angiotensin II EIA Kit, for serum, plasma, culture supernatant and cell lysates
species reactivity
mouse, human, rat
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
enzyme immunoassay: suitable
input
sample type cell lysate
sample type culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 2.62 pg/mL
standard curve range: 0.1-1000 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... AGT(183)
Catégories apparentées
Application
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Angiotensin II EIA Kit has been used for quantitative estimation of serum angiotensin-II.
For research use only. Not for use in diagnostic procedures.
Angiotensin II EIA Kit has been used for analyzing circulating and serum levels of angiotensin II (Ang II) in mice and rats respectively.
Angiotensin II EIA Kit has been used for analyzing circulating and serum levels of angiotensin II (Ang II) in mice and rats respectively.
Biochem/physiol Actions
Study on in vitro model shows that mechanical stretch induced Ang II release plays a vital role in mediating stretch-induced hypertrophic response. Ang II is implicated in maintaining blood pressure and has an important role in hypertension and in the pathophysiology of cardiovascular disorders. Ang II also has an essential role in growth induction, cell migration and mitosis of vascular smooth muscle cells. It enhances the production of collagen type I and III in fibroblasts, that results in thickening of the vascular wall and myocardium, and fibrosis. Variation in Ang II gene increases the risk of myocardial infarction, hypertension and left ventricular hypertrophy. Ang II expression is associated with heart failure, cardiac remodeling, diabetes, and the proliferative and inflammatory responses to arterial injury. The pharmacological agents such as angiotensin II-converting enzyme inhibitors or angiotensin II receptor antagonists can be used for treating Ang II-induced hypertension and congestive heart failure.
General description
The Angiotensin II Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting Angiotensin II peptide based on the principle of Competitive Enzyme Immunoassay. EIA-ANGII-1 can theoretically detect all active angiotensins, including ANGI, ANGII, ANGIII and ANGIV. However, it does not detect inactive angiotensinogen.
Immunogen
Angiotensin II, synthetic peptide
Composants de kit également disponibles séparément
Réf. du produit
Description
FDS
- RABHRP3HRP-Streptavidin
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Classe de stockage
8A - Combustible corrosive hazardous materials
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Genetic abrogation of adenosine A3 receptor prevents uninephrectomy and high salt-induced hypertension
Yang T, et al.
Journal of the American Heart Association, 5(7), e003868-e003868 (2016)
Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro.
Sadoshima J
Cell, 75(5), 977-984 (1993)
Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.
Yang T
Journal of the American Heart Association, 5(7) (2016)
Daniela Volonte et al.
The Journal of biological chemistry, 296, 100242-100242 (2021-01-01)
Oncogenic K-Ras (K-RasG12V) promotes senescence in normal cells but fuels transformation of cancer cells after the senescence barrier is bypassed. The mechanisms regulating this pleiotropic function of K-Ras remain to be fully established and bear high pathological significance. We find
Gagandeep Kaur et al.
Frontiers in physiology, 12, 653045-653045 (2021-06-15)
Background: Tobacco smoking is known to be involved in the pathogenesis of several cardiopulmonary diseases. Additionally, smokers are highly susceptible to infectious agents due to weakened immunity. However, the progression of lung injury based on SARS-CoV-2-mediated COVID-19 pathogenesis amongst smokers
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