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Merck

1045009

USP

Atropine sulfate

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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A propos de cet article

Formule linéaire :
(C17H23NO3)2 · H2SO4 · H2O
Numéro CAS:
5908-99-6
Poids moléculaire :
694.83
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749082
MDL number:
MFCD00074815
Beilstein/REAXYS Number:
6109275

Principaux documents

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SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

grade

pharmaceutical primary standard

API family

atropine

manufacturer/tradename

USP

mp

189-192 °C (A) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Atropine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Atropine Sulfate Injection
  • Atropine Sulfate Ophthalmic Solution
  • Atropine Sulfate Ophthalmic Ointment
  • Diphenoxylate Hydrochloride and Atropine Sulfate Tablets
  • Diphenoxylate Hydrochloride and Atropine Sulfate Oral Solution
  • Atropine

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

A I Jobling et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 696-710 (2014-11-14)
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M K Schultz et al.
Neurotoxicology and teratology, 44, 89-104 (2014-06-20)
The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an
Miklós Palotai et al.
Neurochemical research, 39(8), 1477-1483 (2014-06-05)
The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depression, reward and drug addiction, learning and memory. Previous studies demonstrated that the NOP-receptor
N Snelder et al.
British journal of pharmacology, 171(22), 5076-5092 (2014-06-26)
Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial pressure (MAP), cardiac output (CO) and total peripheral resistance (TPR). The present investigation aims to (i) extend the previously developed model by parsing CO
Francois Malecaze et al.
Investigative ophthalmology & visual science, 55(10), 6712-6721 (2014-09-25)
To characterize the expression of the bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases (collectively called BTPs), which include BMP-1, mammalian tolloid (mTLD), and mammalian tolloid-like 1 (mTLL-1) and 2 (mTLL-2), as well as the associated proteins procollagen C-proteinase enhancers (PCPE-1 and -2)
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