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A propos de cet article
Formule empirique (notation de Hill) :
C29H33ClN2O2 · HCl
Numéro CAS:
Poids moléculaire :
513.50
MDL number:
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
Service technique
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pharmaceutical primary standard
API family
loperamide
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4
InChI
1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
InChI key
PGYPOBZJRVSMDS-UHFFFAOYSA-N
Gene Information
human ... OPRM1(4988)
Application
Loperamide hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Loperamide Hydrochloride Tablets
- Loperamide Hydrochloride Capsules
- Loperamide Hydrochloride Oral Solution
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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H Miyazaki et al.
European journal of drug metabolism and pharmacokinetics, 4(4), 199-206 (1979-01-01)
Following oral administration of [14C]loperamide hydrochloride in 1 mg/kg to rats, plasma levels of radioactivity reached maximum at 4 hrs and decreased with a half-life of 4.1 hrs. Radioactivity in 96-hr feces accounted for 95% of the dose, with 30%
Loperamide hydrochloride.
L M Daugherty
American pharmacy, NS30(12), 45-48 (1990-12-01)
William C Kreisl et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 82-87 (2014-12-17)
The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-brain barrier, and its resultant spare capacity requires substantial blockade to increase the uptake of avid substrates, blunting the ability of investigators to measure clinically meaningful alterations in P-gp function.