Eshmuno® CPX is an innovative, high-resolution platform designed for highly productive downstream purification of monoclonal antibodies. Eshmuno® CPX was specifically designed for high aggregate removal efficiency with outstanding dynamic binding capacity. The result: high resolution intermediate purification with excellent mAb monomer/aggregate separation efficiency
Utilizing a 50 μm diameter base bead and Merck’s proprietary tentacle technology for more effective binding of target substances, Eshmuno® CPX resin exhibits a high resolution and impurity clearance independant of scale and flow rate. Its high binding capacity and excellent pressure flow behaviour results in an outstanding productivity.
|Eshmuno® CPX resin provides:
Excellent removal of mAb monomer/aggregate and impurities
The primary challenge for intermediate purification and polishing is the selectivity to remove impurities similar to the target molecule, such as aggregates and HCP, even at high loading levels. Eshmuno® CPX resin offers these features for different types of biomolecules and demonstrates efficient and consistent clearance of leached protein A and HCP.
Eshmuno® CPX media can operate at elevated linear flow rates with a pressure drop that allows the use of conventional chromatography columns and systems.