N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

Name: N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Brand: SIAL

for GC derivatization, LiChropur^™, ≥95.0% (GC), with 1% tert-Butyldimethylchlorosilane

Synonym(s):

N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, Silylating mixture VI

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All Photos(3)

About This Item

Empirical Formula (Hill Notation):

C₉H₁₈F₃NOSi

CAS Number:

77377-52-7

Molecular Weight:

241.33

UNSPSC Code:

41116105

PubChem Substance ID:

329747171

NACRES:

NA.22

Beilstein/REAXYS Number:

3606546

MDL number:

MFCD00009671

Product Name

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, LiChropur^™, ≥95.0% (GC)

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

grade

derivatization grade ((GC derivatization))

assay

≥95.0% (GC)

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

impurities

0.5-1.5% tert-butyldimethylchlorosilane

storage temp.

2-8°C

Quality Level

100

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Related Categories

Chemical Synthesis

Silanes

Application

MTBSTFA + 1% TBDMSCl can be used as a derivatizing reagentin the analysis of:

Organic acid profile in human serum by gaschromatography/mass spectrometry (GC/MS).
Nerveagents and their breakdown products by GC–MS-MS method.

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamidewith 1% tert-Butyldimethylchlorosilane (TBDMS) is a derivatizing reagentcommonly used in gas chromatography (GC) and gas chromatography-massspectrometry (GC-MS).

Other Notes

Discover LiChropur^™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS02,GHS07

signalword

Warning

hcodes

H226,H315,H319

pcodes

P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

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Gas chromatography/mass spectrometry analysis of organic acid profiles in human serum: A protocol of direct ultrasound-assisted derivatization

Zhang MJ, et al.

Rapid Communications in Mass Spectrometry, 35(17), e9149-e9149 (2021)

Mass spectrometry of anabolic steroids as their tert-butyldimethylsilyl ether derivatives.

Steffenrud, S.

Rapid Communications in Mass Spectrometry, 10, 1698-1702 (1996)

The Application of a single-column GC--MS-MS method for the rapid analysis of chemical warfare agents and breakdown products

Young SA, et al.},

Journal of Analytical Toxicology, 43(3), 179-187 (2019)

Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation.

Yalun Arifin et al.

Applied microbiology and biotechnology, 98(21), 9033-9044 (2014-08-16)

Sugarcane is the most efficient large-scale crop capable of supplying sufficient carbon substrate, in the form of sucrose, needed during fermentative feedstock production. However, sucrose metabolism in Escherichia coli is not well understood because the two most common strains, E.

Hepatic and fecal metabolomic analysis of the effects of Lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice.

Xue Shi et al.

Journal of proteome research, 14(2), 1174-1182 (2015-01-17)

The interactions among the gut, liver, and immune system play an important role in liver disease. Probiotics have been used for the treatment and prevention of many pathological conditions, including liver diseases. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF

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