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Merck

BP576

Hydrocortisone

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
1354819
MDL number:
MFCD00011654

Product Name

Hydrocortisone, British Pharmacopoeia (BP) Assay Standard

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

grade

pharmaceutical primary standard

API family

hydrocortisone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

211-214 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

Gene Information

human ... NR3C1(2908)

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Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Primary glucocorticoid secreted by the adrenal cortex.

Application

Hydrocortisone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Tretinoin, Hydrocortisone and Hydroquinone Cream
  • Miconazole and Hydrocortisone Acetate Cream
  • Hydrocortisone Sodium Succinate Injection
  • Prednisolone Tablets
  • Miconazole and Hydrocortisone Cream
  • Miconazole and Hydrocortisone Ointment
  • Hydrocortisone and Neomycin Cream
  • Hydrocortisone and Clioquinol Ointment
  • Hydrocortisone Sodium Phosphate Oral Solution
  • Prednisolone Gastro-resistant Tablets
  • Hydrocortisone Sodium Phosphate
  • Hydrocortisone Sodium Phosphate Injection
  • Hydrocortisone and Clioquinol Cream
  • Methylprednisolone Tablets
  • Hydrocortisone Acetate Oral Suspension
  • Hydrocortisone Cream
  • Hydrocortisone Oromucosal Tablets

    • General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
    For further information and support please go to the website of the issuing Pharmacopoeia.

    Other Notes

    Sales restrictions may apply.
    Learn how British Pharmacopoeia (BP) sets the standard by offering quality British Pharmacopoeia Chemical Reference Substances (BPCRS).

    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    Hazard Classifications

    Repr. 1A - STOT RE 2

    target_organs

    Adrenal gland,Bone marrow

    Storage Class

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Florian Hardeveld et al.
    Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
    Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
    Lorenz Goette et al.
    Psychoneuroendocrinology, 54, 115-123 (2015-02-24)
    Social competition is a fundamental mechanism of evolution and plays a central role in structuring individual interactions and communities. Little is known about the factors that affect individuals' competitive success, particularly in humans. Key factors might include stress, a major
    Nirit Geva et al.
    Pain, 155(11), 2418-2425 (2014-09-25)
    Anecdotes on the ability of individuals to continue to function under stressful conditions despite injuries causing excruciating pain suggest that acute stress may induce analgesia. However, studies exploring the effect of acute experimental stress on pain perception show inconsistent results
    Marianne Oksnes et al.
    The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)
    Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)
    Kenji Ohba et al.
    PloS one, 9(5), e97787-e97787 (2014-05-27)
    High prevalence of infection with high-risk human papilloma virus (HPV) ranging from 25 to 100% (average 31%) was observed in breast cancer (BC) patients in Singapore using novel DNA chip technology. Early stage of BC demonstrated higher HPV positivity, and
    View All Related Papers

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