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Merck

F0300000

Folic acid

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
59-30-3
Molecular Weight:
441.40
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329799653
MDL number:
MFCD00079305
Beilstein/REAXYS Number:
100781

Product Name

Folic acid, European Pharmacopoeia (EP) Reference Standard

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

biological source

synthetic

grade

pharmaceutical primary standard

API family

folic acid

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

>285 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Folic acid may be used as an European Pharmacopoeia reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Folic acid, a water-soluble B vitamin, is available in several food products. As it is not generated in the human body, diet is one of the easiest ways to obtain it. It plays a crucial role in the biochemical synthesis and repair of DNA and is used in the management of megaloblastic anemias, neural tube defects such as anencephaly and spina bifida. Pharmaceutical drug forms of folic acid are desirable for supplementing its consumption through the diet.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Folic acid hydrate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6(5-6), 5662-5663 (2018)
Flow injection chemiluminometric determination of folic acid in pharmaceutical formulations
Al-Warthan.AA
Analytical Sciences, 10(6), 919-922 (1994)
Adsorptive stripping voltammetric determination of folic acid in pharmaceutical preparations
Szczepaniak W and Ren M
Electroanalysis, 6(5-6), 505-507 (1994)
A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests
Matias R, et al.
Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)
Determination of folic acid in tablets by microemulsion electrokinetic chromatography
Aurora-Prado SM, et al.
Journal of Chromatography A, 1051(1-2), 291-296 (2004)
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