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Merck

1085003

USP

Caffeine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1H-Purine-2,6-dione, 1,3,7-Trimethylxanthine

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About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
58-08-2
Molecular Weight:
194.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749194
MDL number:
MFCD00005758
Beilstein/REAXYS Number:
17705

Product Name

Caffeine, United States Pharmacopeia (USP) Reference Standard

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

grade

pharmaceutical primary standard

API family

pentoxifylline, caffeine, dimenhydrinate

manufacturer/tradename

USP

mp

234-236.5 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Caffeine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Caffeine Citrate Injection
  • Caffeine Citrate Oral Solution
  • Acetaminophen and Caffeine Tablets
  • Ergotamine Tartrate and Caffeine Tablets
  • Butalbital, Aspirin, and Caffeine Capsules
  • Ergotamine Tartrate and Caffeine Suppositories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Acetaminophen and Caffeine Tablets
United States Pharmacopeia, 41(2), 51-51 (2020)
Caffeine Citrate Oral Solution
United States Pharmacopeia, 30(5), 663-663 (2013)
Quantitative reversed-phase high-performance liquid chromatographic analysis of ampicillin
Margosis M, et al.
Journal of Chromatography A, 236(2), 461-468 (1982)
Analysis of multicomponent formulations containing phenylpropanolamine hydrochloride, caffeine and diazepam by using LC
Pistos.C and Stewart.TJ
Journal of Pharmaceutical and Biomedical Analysis, 25, 493-499 (2001)
Ergotamine Tartrate and Caffeine Tablets
United States Pharmacopeia, 40(1), 1681-1681 (2015)
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