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Merck

1286005

USP

Folic acid

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
59-30-3
Molecular Weight:
441.40
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749907
MDL number:
MFCD00079305
Beilstein/REAXYS Number:
100781

Product Name

Folic acid, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

grade

pharmaceutical primary standard

API family

folic acid

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Folic acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Folic Acid Tablets
  • Folic Acid Injection
  • Folic Acid Compounded Oral Solution
  • Oil- and Water-Soluble Vitamins with Minerals Chewable Gels
  • Leucovorin Calcium
  • Calcium l-5-Methyltetrahydrofolate Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Folic Acid Tablets
United States Pharmacopeia, 48(3), 2028-2028 (2022)
Folic Acid Compounded Oral Solution
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(5), 2027-2027 (2017)
Folic Acid
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 29(2), 2026-2026 (2020)
Folic Acid assay
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 6689-6689 (2022)
Zohra S Lassi et al.
The Cochrane database of systematic reviews, 3(3), CD006896-CD006896 (2013-04-02)
During pregnancy, fetal growth causes an increase in the total number of rapidly dividing cells, which leads to increased requirements for folate. Inadequate folate intake leads to a decrease in serum folate concentration, resulting in a decrease in erythrocyte folate
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