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Merck

1559006

USP

Prednisone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,4-Pregnadiene-17α,21-diol-3,11,20-trione, 1-Cortisone, 17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone

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About This Item

Empirical Formula (Hill Notation):
C21H26O5
CAS Number:
53-03-2
Molecular Weight:
358.43
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750938
MDL number:
MFCD00003608
Beilstein/REAXYS Number:
2065301

Product Name

Prednisone, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

SMILES string

O=C1C=C[C@@]2(C)C(CC[C@]([C@@](CC[C@@]3(C(CO)=O)O)([H])[C@]3(C)C4)([H])[C@]2([H])C4=O)=C1

grade

pharmaceutical primary standard

API family

prednisone

manufacturer/tradename

USP

mp

236-238 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... NR3C1(2908)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Prednisone USP reference standard for specified quality tests and assay use.

Also used to prepare standard, standard stock and internal standard solutions for the assay and performance tests according to the given below monographs of United States Pharmacopeia (USP):
  • Prednisone
  • Prednisone Tablets
  • Prednisone Oral Solution
  • Hydrocortisone Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H373

Hazard Classifications

STOT RE 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Prednisone Oral Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 30(1), 3671-3671 (2020)
Prednisone Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(3), 3672-3672 (2020)
Prednisone
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 3670-3670 (2020)
Hydrocortisone Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(6), 2234-2234 (2020)
Ronald de Wit
European journal of cancer (Oxford, England : 1990), 41(4), 502-507 (2005-03-02)
Until now, the use of systemic chemotherapy for advanced androgen-independent prostate cancer has had very little to offer to patients. However, in 2004, two large randomised trials investigating docetaxel vs. mitoxantrone have both demonstrated survival improvements, and, in one of
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