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8.17001

Polyethylene glycol

Name: Polyethylene glycol
Brand: MM

200, EMPROVE^® ESSENTIAL, DAB 8, NF

Synonym(s):

Poly(ethylene glycol), Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 200, PEG

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About This Item

Linear Formula:

H(OCH₂CH₂)_nOH

CAS Number:

25322-68-3

UNSPSC Code:

13111021

EC Index Number:

500-038-2

MDL number:

MFCD00081839

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Properties

Quality Level

500

agency

DAB 8, NF

vapor pressure

<0.01 hPa ( 20 °C)

product line

EMPROVE^® ESSENTIAL

form

liquid

autoignition temp.

350 °C (DIN 51794)

mol wt

average M_n 200

pH

5-7 (20 °C, 100 g/L in H₂O)

bp

>150 °C

mp

-50 °C

transition temp

flash point 180 °C

solubility

soluble 70 g/L

density

1.124 g/cm³ at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solubility enhancement

storage temp.

no temp limit

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

When working on a pharmaceutical formulation, there are specific considerations to make and challenging hurdles to take before you can successfully launch your final drug product - formulation stability, release kinetics and bioavailability limitations just to name a few. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Polyethylene glycol (PEG) is a multipurpose polymer which can be applied in solid, semi-solid and liquid formulations. Its broad functional spectrum includes e.g. improvement of API solubility, acting as a lubricant for tablet coating, function as a carrier, and many more. Our comprehensive portfolio of PEGs comprises diverse polymer sizes of different molecular weights to meet your specific application and needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

281.5 °F - closed cup

flash_point_c

138.6 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water soluble liquid

fsl

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Articles

Liquid Formulation Solubility Enhancement

Discover strategies to enhance solubility in injectable formulations using excipients, including cyclodextrins, meglumine, and polyethylene glycols.

Strategies for the Development of Safe and Effective Pediatric Formulations

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.

Global Trade Item Number

SKU	GTIN
8.17001.5000	04022536424064