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Merck

M0200000

Mannitol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

D-Mannitol, Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
69-65-8
Molecular Weight:
182.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817740
MDL number:
MFCD00064287
Beilstein/REAXYS Number:
1721898

Key Documents

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InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

grade

pharmaceutical primary standard

API family

mannitol

manufacturer/tradename

EDQM

mp

167-170 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:

  • Reference solution (b) in the testing of related substances using liquid chromatography (General text 2.2.29) in isomalt, according to the monograph 1531
  • Reference solutions (a) in the identification of mannitol using thin-layer chromatography (General text 2.2.27) and infra-red spectroscopy and testing of related substances and assay using liquid chromatography (General text 2.2.29), according to the monograph 0559
  • Reference solution (b) in the identification of sorbitol using thin-layer chromatography (General text 2.2.27), according to the monograph 0435
  • Reference solution (b) in the testing of related substances using gas chromatography (General text 2.2.28), according to the monograph 1381

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

M0200000-1EA: + M0200000: + M0200000-1200MG:

jan

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Sorbitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3865-3867 (2019)
Mannitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3175-3176 (2019)
Isomalt
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 2998-2999 (2019)
Xylitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 4223-4225 (2016)
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
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