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PHR1150

Acetaminophen Related Compound F

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Nitrophenol, Paracetamol Impurity F, p-Nitrophenol

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About This Item

Linear Formula:
O2NC6H4OH
CAS Number:
100-02-7
Molecular Weight:
139.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823168
EC Number:
202-811-7
Beilstein/REAXYS Number:
1281877
MDL number:
MFCD00007331
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1003064

vapor pressure

0.6 mmHg ( 120 °C)

API family

acetaminophen, paracetamol

CofA

current certificate can be downloaded

autoignition temp.

541 °F

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

279 °C (lit.)

mp

110-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O=N(C1=CC=C(O)C=C1)=O

InChI

1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H

InChI key

BTJIUGUIPKRLHP-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8987 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT RE 2 - STOT RE 2 Oral

target_organs

Kidney,Liver

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

336.2 °F

flash_point_c

169 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 5: Self-reactive substances + Nitro compounds + Hazardous rank II + 2nd self-reactive materials

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

GC Analysis of Phenols in Water

Analytical standard separation of various phenols for research and industrial applications.

Ali Mehdinia et al.
Journal of chromatography. A, 1283, 82-88 (2013-03-08)
In this study, an analytical procedure for the selective extraction and detection of 4-nitrophenol (4-NP) was investigated by using of molecularly imprinted polymer on the surface of magnetic nanoparticles (MNPs). The magnetic nanoparticles were modified by tetraethyl orthosilicate (TEOS) and
Ipsita K Sen et al.
Carbohydrate polymers, 91(2), 518-528 (2012-11-06)
Gold nanoparticles were synthesized by reducing chloroauric acid with a glucan, isolated from an edible mushroom Pleurotus florida, cultivar Assam Florida. Here, glucan acts as reducing as well as stabilizing agent. The synthesized gold nanoparticles were characterized by UV-visible spectroscopy
Siew Hong Lam et al.
Biochimica et biophysica acta, 1830(10), 4778-4789 (2013-06-25)
4-Nitrophenol (4-NP) is a prioritized environmental pollutant and its toxicity has been investigated using zebrafish, advocated as an alternative toxicological model. However, molecular information of 4-NP induced hepatotoxicity is still limited. This study aimed to obtain molecular insights into 4-NP-induced
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