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345547

Hydrogen chloride solution

4.0 M in dioxane

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
7647-01-0
Molecular Weight:
36.46
NACRES:
NA.21
PubChem Substance ID:
329755029
UNSPSC Code:
12352301
MDL number:
MFCD00011324
Concentration:
3.80-4.40 M (by NaOH, titration), 4.0 M in dioxane
Form:
liquid
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form

liquid

Quality Level

200

concentration

3.80-4.40 M (by NaOH, titration), 4.0 M in dioxane

density

1.05 g/mL at 25 °C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

General description

Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.

Application

Hydrogen chloride solution (4.0 M in dioxane) can be used as:     
  • A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.     
  • A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.      
  • A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).

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Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

flash_point_f

62.6 °F - closed cup

flash_point_c

17 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Deleterious substance

pdsc

Class I Designated Chemical Substances

prtr

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water insoluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

345547-2L:4.548173138282E12 + 345547-100ML:4.548173138275E12 + 345547-800ML:4.548173138299E12

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB1585
MKCZ5444
MKCZ0819
MKCX6335
MKCX1684

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Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m)
G H, et al.
The Journal of Peptide Research, 4, 338-341 (2001)
Preparation of N-9-fluorenylmethoxycarbonylamino acid chlorides from mixed anhydrides by the action of hydrogen chloride 1
FRANCIS C MF, et al.
International Journal of Peptide and Protein Research, 38, 97-102 (1991)
Surface-and redox-active multifunctional polyphenol-derived poly (ionic liquid) s: controlled synthesis and characterization
Patil N, et al.
Macromolecules, 49(20), 7676-7691 (2016)
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