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Merck

A4929

N,N′-Bis(acryloyl)cystamine

BioReagent, suitable for electrophoresis

Synonym(s):

2,2′-(Bisacrylamino)diethyl disulfide, BAC, Bis(2-acrylamidoethyl) disulfide

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O2S2
CAS Number:
60984-57-8
Molecular Weight:
260.38
NACRES:
NA.25
PubChem Substance ID:
24890926
UNSPSC Code:
12352116
EC Number:
262-546-8
MDL number:
MFCD00036225
Form:
powder

Key Documents

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Quality Level

200

InChI key

DJVKJGIZQFBFGS-UHFFFAOYSA-N

InChI

1S/C10H16N2O2S2/c1-3-9(13)11-5-7-15-16-8-6-12-10(14)4-2/h3-4H,1-2,5-8H2,(H,11,13)(H,12,14)

SMILES string

C=CC(=O)NCCSSCCNC(=O)C=C

product line

BioReagent

form

powder

suitability

suitable for electrophoresis

storage temp.

−20°C

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Application

BAC is used as a reversible cross-linker for polyacrylamide gels, to simplify isolation of macromolecules separated on the gels. The disulfide linkage can be broken with a suitable reducing agent. A 1-g slice of a 4% (12:1) gel will dissolve in 5 mL of 100 mM DTT in TBE (pH 8.3) in less than 30 min.
BAC is used as a reversible cross-linker for polyacrylamide gels. The disulfide linkage can be broken with a suitable reducing agent. A 12:1 ratio of acrylamide:BAC is recommended for DNA purification. A one gram slice of a 4% gel will dissolve in 5 mL of 100 mM DTT, TBE solution (pH 8.3) in less than 30 min. The pH of 8.3 is optimum for rapid dissolution of the gel.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

A4929-1G: + A4929-VAR: + A4929-5G: + A4929-INTR: + A4929-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000467137
0000467137
0000414165
0000414165
0000398898

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Hiroko Sano et al.
PLoS genetics, 11(5), e1005209-e1005209 (2015-05-29)
The coordination of growth with nutritional status is essential for proper development and physiology. Nutritional information is mostly perceived by peripheral organs before being relayed to the brain, which modulates physiological responses. Hormonal signaling ensures this organ-to-organ communication, and the
Nick Orr et al.
Human molecular genetics, 24(10), 2966-2984 (2015-02-06)
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52
Na-Yu Chia et al.
Gut, 64(5), 707-719 (2014-07-24)
Gastric cancer (GC) is a deadly malignancy for which new therapeutic strategies are needed. Three transcription factors, KLF5, GATA4 and GATA6, have been previously reported to exhibit genomic amplification in GC. We sought to validate these findings, investigate how these
Kevin R Bushell et al.
Blood, 125(6), 999-1005 (2014-12-04)
Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas
Sehrish Rafique et al.
Genome biology, 16, 145-145 (2015-08-04)
Epigenetic changes are being increasingly recognized as a prominent feature of cancer. This occurs not only at individual genes, but also over larger chromosomal domains. To investigate this, we set out to identify large chromosomal domains of epigenetic dysregulation in
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