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Merck

1006801

USP

Acetone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2-propanone

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About This Item

Linear Formula:
CH3COCH3
CAS Number:
67-64-1
Molecular Weight:
58.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329748883
MDL number:
MFCD00008765
Beilstein/REAXYS Number:
635680

Key Documents

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InChI

1S/C3H6O/c1-3(2)4/h1-2H3

SMILES string

CC(C)=O

InChI key

CSCPPACGZOOCGX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

vapor density

2 (vs air)

vapor pressure

184 mmHg ( 20 °C)

form

liquid

expl. lim.

13.2 %

manufacturer/tradename

USP

availability

not available in (Sales restrictions may apply)

refractive index

n20/D 1.359 (lit.)

bp

56 °C/760 mmHg (lit.)

mp

−94 °C (lit.)

density

0.791 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetone USP reference standard for use in specified quality tests and assays.

Also used to prepare standard and system suitability solutions for the assay, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Acetone
  • Methyl Alcohol
  • Doxorubicin Hydrochloride
Acetone′s luminesence intensity is dependent upon the solution components . The absorption of UV light by acetone, results in its photolysis and the production of radials .

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

flash_point_f

1.4 °F - closed cup

flash_point_c

-17.0 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 1 petroleums + Hazardous rank II + Water soluble liquid

fsl

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

1006801-3AMP:4548173341187 + 1006801-3X1.5ML:

jan

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Certificates of Analysis (COA)

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Methyl Alcohol
United States Pharmacopeia, 34(5), 5882-5882 (2020)
Doxorubicin Hydrochloride
United States Pharmacopeia, 40(3), 1512-1512 (2020)
Acetone
United States Pharmacopeia, 34(1), 5600-5600 (2020)
Len Verbeke et al.
Hepatology (Baltimore, Md.), 59(6), 2286-2298 (2013-11-22)
The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We studied the effect of short-term treatment with obeticholic acid (INT-747), a potent selective FXR
Wanqiang Sheng et al.
Cell research, 24(12), 1387-1402 (2014-11-22)
T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5
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