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Merck

1576708

USP

Propylene glycol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,2-Propanediol, Propylene glycol

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About This Item

Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
57-55-6
Molecular Weight:
76.09
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750993
MDL number:
MFCD00064272
Beilstein/REAXYS Number:
1340498

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InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

SMILES string

CC(O)CO

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

grade

pharmaceutical primary standard

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

API family

propylene glycol

autoignition temp.

779 °F

expl. lim.

12.5 %

manufacturer/tradename

USP

refractive index

n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Propylene glycol USP reference standard intended for use in specified quality tests and assays.

Also used to prepare standard stock, standard, sample, system suitability, and sensitivity solution for assay and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Propylene Glycol Dilaurate
  • Phenytoin Sodium Injection
  • Hydroxypropyl Betadex
  • Butylene Glycol

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

219.2 °F - closed cup

flash_point_c

104 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Group 4: Flammable liquids + Type 3 petroleums + Hazardous rank III + Water soluble liquid

fsl

1576708-1G: + 1576708-5X1ML: + 1576708-1ML:

jan

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Butylene Glycol
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(5), 5653-5653 (2020)
Hydroxypropyl Betadex
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 32(5), 5818-5818 (2020)
Phenytoin Sodium Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(5), 3534-3534 (2020)
Propylene Glycol Dilaurate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 35(3), 5989-5989 (2013)
J O Funk et al.
Contact dermatitis, 31(4), 236-241 (1994-10-01)
Evaluation of dermatitis associated with propylene glycol application or ingestion remains a challenge. The research dealing with skin reactions to propylene glycol is revisited and new aspects for future research are outlined. Based on literature review and our own observations
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