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Merck

FCMAB104A4

Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor™ 488

clone 3H10, from mouse, ALEXA FLUOR™ 488

別名:

H3 histone, family 3A, H3S10P, Histone H3 (phospho S10), H3 histone, family 3A, H3 histone, family 3B, H3 histone, family 3B (H3.3B)

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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製品名

Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor™ 488, clone 3H10, from mouse, ALEXA FLUOR™ 488

biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3H10, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

NM_003493

UniProt accession no.

Q16695

shipped in

wet ice

target post-translational modification

phosphorylation (pSer10)

Quality Level

100

Gene Information

human ... HIST1H3F(8968)

関連するカテゴリー

Biochem/physiol Actions

Broad species cross-reactivity is expected.
Histone H3 phosphorylated at Ser10

Analysis Note

Control
Jurkat Cells
Evaluated by Flow Cytometry with Jurkat cells.

Application

Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor™ 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Alexa Fluor 488 and validated for use in FC.
Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer
Research Sub Category
Histones

Cell Cycle, DNA Replication & Repair

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
17 kDa observed

Immunogen

A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.
Epitope: Ser10

Physical form

Protein G Purified
Purified mouse IgG1k conjugated to Alexa Fluor™ 488 in PBS with 15mg/mL BSA and less than 0.09% sodium azide.

Preparation Note

Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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保管分類

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Anna Tervasmäki et al.
International journal of cancer, 145(8), 2070-2081 (2019-02-28)
Strong inherited predisposition to breast cancer is estimated to cause about 5-10% of all breast cancer cases. As the known susceptibility genes, such as BRCA1 and BRCA2, explain only a fraction of this, additional predisposing genes and related biological mechanisms
Hong Shik Yun et al.
Molecular cancer therapeutics, 20(9), 1672-1679 (2021-06-24)
AZD0530, a potent small-molecule inhibitor of the Src kinase family, is an anticancer drug used in the treatment of various cancers. In the case of glioblastoma (GBM), where resistance to radiotherapy frequently occurs, Src kinase is known as one of
Govind M Pai et al.
Oncotarget, 7(51), 85365-85380 (2016-11-20)
Tuberous Sclerosis (TSC) is characterized by exorbitant mTORC1 signalling and manifests as non-malignant, apoptosis-prone neoplasia. Previous reports have shown that TSC-/- cells are highly susceptible to mild, innocuous doses of genotoxic stress, which drive TSC-/- cells into apoptotic death. It

グローバルトレードアイテム番号

カタログ番号GTIN
FCMAB104A404053252671241

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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