920622
4-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)picolinic acid
別名:
Rigid linker for PROTAC® development
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この商品について
実験式（ヒル表記法）:
C19H25N3O5
分子量:
375.42
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
eCl@ss:
32039090
form
powder
Quality Segment
reaction suitability
reagent type: linker
technique(s)
targeted protein degradation: suitable
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=NC(C(O)=O)=C3)C1)=O)C
InChI
1S/C19H25N3O5/c1-18(2,3)27-17(26)21-11-19(12-21)7-4-5-9-22(16(19)25)13-6-8-20-14(10-13)15(23)24/h6,8,10H,4-5,7,9,11-12H2,1-3H3,(H,23,24)
InChI key
FLGFEMZHQLDUOT-UHFFFAOYSA-N
Application
4-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)picolinic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920592
920711
920614
920630
Similar linkers in this series:
920592
920711
920614
920630
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
保管分類
11 - Combustible Solids
WGK
WGK 3
引火点 (F)
Not applicable
引火点（°C）
Not applicable