939412
ブチルリチウム 溶液
2.5 M (in PAO/hexanes mixture)
別名:
n-BuLi, n-ブチルリチウム 溶液, ブチルリチウム, リチウム-1-ブタニド
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この商品について
化学式:
CH3(CH2)3Li
CAS番号:
分子量:
64.06
UNSPSC Code:
12352142
Beilstein/REAXYS Number:
1209227
MDL number:
NACRES:
NA.22
form
liquid
Quality Segment
concentration
2.5 M (in PAO/hexanes mixture)
color
colorless to yellow
storage temp.
2-8°C
SMILES string
[Li]CCCC
InChI
1S/C4H9.Li/c1-3-4-2;/h1,3-4H2,2H3;
InChI key
MZRVEZGGRBJDDB-UHFFFAOYSA-N
General description
n-Butyllithium (n-BuLi) is an organolithium reagent commonly used as a strong base in organic synthesis. It is also used as a lithium source for a wide range of lithium bases, such as lithium amides, acetylides, and alkoxides. This n-BuLi is a solution in poly-α-olefin (PAO)/hexanes solvent mixture is considered non-pyrophoric which is demonstrated using EPA’s SW-846 Test Method 1050.
Application
n-BuLi can be used as a strong base to form corresponding lithium salts by the deprotonation of nitrogen, oxygen, phosphorus, and carbon acids. Heterocyclic compounds, such as furans, thiophenes, oxazoles, pyrroles, etc, can be lithiated α to the ring heteroatom using n-BuLi. These lithiated salts react in situ with alkyl halides to obtain useful organic compounds by the formation of the C-C bond. n-BuLi is also a useful reagent for lithium–halogen exchange reactions. Synthesis of various other useful reagents such as lithium diisopropylamide (LDA) and diphenylphosphine is done by in situ reaction with n-BuLi In the polymerization of dienes, n-BuLi is employed as an initiator.
The product is also used in the following reactions:
The product is also used in the following reactions:
- Anionic rearrangement reactions
- Metal-halogen interchange and transmetalation reactions
- Elimination reactions
- [1,2]- and [1,4]-Wittig rearrangement reaction
- Anionic homo-Fries rearrangement reaction
- Asymmetric carbolithiation
Features and Benefits
This n-BuLi formulation in PAO/hexanes is:
- Considered non-pyrophoric demonstrated using EPA’s SW-846 Test Method 1050
- Maintains the same reactivity as traditional n-BuLi reagents
- Compatible with traditional lithiation additives like KOtBu or TMEDA
- More bench stable than traditional n-BuLi reagents
Packaging
Packaged in Sure/Seal™bottles.
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
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Danger
target_organs
Nervous system
supp_hazards
flash_point_f
88.7 °F
flash_point_c
31.5 °C
Hazard Classifications
Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 3 - Repr. 2 - Skin Corr. 1B - STOT RE 1 Inhalation - Water-react. 1
保管分類
4.3 - Hazardous materials which set free flammable gases upon contact with water
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
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名称等を通知すべき危険物及び有害物
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