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1.00202

N,N-ジメチルホルムアミド

for headspace gas chromatography SupraSolv®

別名:

DMF, NSC 5356

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この商品について

化学式:
HCON(CH3)2
CAS番号:
68-12-2
分子量:
73.09
UNSPSC Code:
12191502
NACRES:
NA.03
EC Index Number:
200-679-5
MDL number:
MFCD00003284
Beilstein/REAXYS Number:
605365
Assay:
≥99.8% (GC)
Technique(s):
GC-HS: suitable
Bp:
153 °C (lit.)
Vapor pressure:
2.7 mmHg ( 20 °C)
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Quality Segment

agency

according to Ph. Eur., according to USP

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

product line

SupraSolv®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

833 °F

potency

3010 mg/kg LD50, oral (Rat), 1500 mg/kg LD50, skin (Rabbit)

contains

2-Methyl-2-butene as stabilizer

expl. lim.

15.2 %

technique(s)

GC-HS: suitable

impurities

≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH, ≤0.05% Water

evapn. residue

≤3.0 mg/L

color

APHA: ≤10

refractive index

n20/D 1.430 (lit.)

pH

7 (20 °C, 200 g/L in H2O)

bp

153 °C (lit.)

mp

−61 °C (lit.)

transition temp

flash point 57.5 °C

density

0.944 g/mL (lit.)

SMILES string

[H]C(=O)N(C)C

storage temp.

2-30°C

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

General description

SupraSolv® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.

Application

SupraSolv® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.
多くの疎水性有機化合物に用いられる溶媒です。

Features and Benefits

  • Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
  • Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
  • Batch-to-batch consistency, ensuring reproducibility across analytical campaigns

Analysis Note

SupraSolv® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:
  • Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
  • Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
  • Class 3 solvents (low toxic potential): ≤ 50 µg/gThese specifications are verified lot-by-lot via GC/HS analysis, providing robust certification of compliance and analytical traceability.

Other Notes

Complete GC Workflow Guide for ICH Q3C(R9) and USP<467>Compliance

Explore various labsafety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

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注意喚起語

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

保管分類

3 - Flammable liquids

一体何が起きているの？

WGK 2

引火点 (F)

135.5 °F - closed cup

引火点（°C）

57.5 °C - closed cup

ピクトグラム

FlameHealth hazardExclamation mark
GHS02,GHS08,GHS07

ハザードコード

H226,H312 + H332,H319,H360D

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

第4類:引火性液体 + 第二石油類 + 危険等級III + 水溶性液体

fsl

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

第一種指定化学物質

prtr

1002020000: + 1002021000:4548174003671 + 1002022508: + 1002020500: + 1002022500: + 1002020501:

jan

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