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104550

ACA

Name: ACA
Brand: MM

A cell-permeable inhibitor of phospholipase A2 that blocks epinephrine-stimulated thromboxane production in platelets.

別名:

ACA, N-( p-Amylcinnamoyl)anthranilic Acid, N-(p-Amylcinnamoyl)anthranilic Acid

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この商品について

実験式（ヒル表記法）:

C₂₁H₂₃NO₃

CAS番号:

110683-10-8

分子量:

337.41

MDL number:

MFCD00211365

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 10 mg/mL, DMSO: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

N(c2c(cccc2)C(=O)O)C(=O)\C=C\c1ccc(cc1)CCCCC

InChI

1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+

InChI key

GAMRBCZMOOMBSQ-CCEZHUSRSA-N

詳細

General description

A cell-permeable inhibitor of phospholipase A₂ that blocks epinephrine-stimulated thromboxane production in platelets. Inhibits ATP-stimulated phosphatidylcholine (PC) secretion in alveolar type II cells. Also blocks phorbol ester and A23187-induced PC secretion in type II cells. Reported to block glucose-induced insulin secretion by pancreatic β-cells. Exhibits moderate leukotriene antagonist activity.

Inhibits epinephrine-stimulated thromboxane production (86% at 3.5 μM) via inhibition of phospholipase A₂ (PLA₂) in human platelets. Also blocks glucose-induced insulin secretion in pancreatic islets. Possesses moderate leukotriene antagonist activity.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
A2PLA2

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Liu, L., et al. 1999. J. Cell. Biochem.72, 103.
Simonsson, E., et al. 1998. Diabetes47, 1436.
Konrad, R.J., et al. 1992. Biochim. Biophys. Acta1135, 215.
Banga, H.S., et al. 1986. Proc. Natl. Acad. Sci. USA83, 9197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c