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1.12422

N-Acetyl-L-cysteine

Name: N-Acetyl-L-cysteine
Brand: MM

for biochemistry

別名:

N-Acetyl-L-cysteine, 2-Acetamido-3-mercaptopropionic acid

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この商品について

実験式（ヒル表記法）:

C₅H₉NO₃S

CAS番号:

616-91-1

分子量:

163.19

UNSPSC Code:

12352209

EC Index Number:

210-498-3

NACRES:

NA.21

MDL number:

MFCD00004880

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特性

vapor pressure

<1 hPa ( 20 °C)

Quality Level

100

form

solid

potency

5050 mg/kg LD₅₀, oral (Rat)

pH

1.5-2.5 (20 °C, 100 g/L in H₂O)

mp

110.4 °C

solubility

179.5 g/L

density

1.48 g/cm³ at 20 °C

bulk density

730 kg/m³

storage temp.

2-30°C

SMILES string

SCC(NC(=O)C)C(=O)O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)

InChI key

PWKSKIMOESPYIA-UHFFFAOYSA-N

詳細

Application

Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis: This study presents a novel N-Acetyl-L-cysteine application in aerosol form designed to treat Pseudomonas aeruginosa biofilm infections in cystic fibrosis patients, highlighting its potential to improve pulmonary function and reduce bacterial colonization (Alhajj et al., 2024).

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells: Research indicates that N-Acetyl-L-cysteine, as part of a combinatory therapy, enhances the oxidative stress response in acute myeloid leukemia, providing a therapeutic strategy for targeting leukemia stem cells (Silva et al., 2024).

N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses: This meta-analysis reveals N-Acetyl-L-cysteine′s effectiveness in reducing exacerbations and improving antioxidant defense in COPD and chronic bronchitis, suggesting a significant therapeutic benefit in respiratory disease management (Papi et al., 2024).

Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats: N-Acetyl-L-cysteine, used in modifying magnetic nanoparticles, shows promising results in reducing oxidative stress and liver damage in a prediabetic rat model, underscoring its potential in preventive therapies (Świętek et al., 2024).

Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by NAC: This research outlines N-Acetyl-L-cysteine′s role in mitigating oxidative stress and ferroptosis in corneal cells, providing insights into its protective effects against chemical-induced ocular damage (Kandhari et al., 2023).

Analysis Note

Assay (iodometric): ≥ 99.0 %
Identity (IR-spectrum): passes test
Appearance: white to almost white, crystalline powder or colorless crystals
Appearance of solution (1 mol/l, water): clear and colorless
Spec. rotation (α 20/D, 50 g/l, buffer pH 7.0): +21.0 to +27.0
Heavy metals (as Pb): ≤ 0.001 %
NH₄ (Ammonium): ≤ 0.01 %
L-cysteine (HPLC): ≤ 0.02 %
Other ninhydrine positive substances: ≤ 0.1 %

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pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

保管分類

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c