118510
ATR Kinase Inhibitor II
別名:
ATR Kinase Inhibitor II, 3-Amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide
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この商品について
実験式（ヒル表記法）:
C22H25N5O3S
分子量:
439.53
NACRES:
NA.54
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥97% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
A cell-permeable aminopyrazinyl-sulfone compound that acts as a potent, reversible and ATP-competitive inhibitor of ATR kinase (IC50 = 12 nM; Ki = 6 nM) with excellent selectivity over ATM, DNA-PK (IC50 >8 µM) and in a 50-kinase panel (% inhibition at 2 µM = 59, 57, 55, 52, 43 and 42 for AMPK, Lck, RIPK2, Ret, IKKα and FGFR3, respectively). Shown to block pH2AX-Ser139 (IC50 = 420 nM in hydroxyurea treated HT29 cells) and preferentially enhance cisplatin (Cat. No. 232120 ) cytotoxicity against tumor cells over normal cells by ~7-fold at 620 nM.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Charrier, J.D., et al. 2011. J. Med. Chem.54, 2320.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 2
引火点 (F)
Not applicable
引火点（°C）
Not applicable