124005
Akt Inhibitor
≥98% (NMR), Akt (PKB) and PI 3-K inhibitor, solid
別名:
Akt Inhibitor, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl- sn-glycerocarbonate, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate
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この商品について
実験式（ヒル表記法）:
C30H58O10
分子量:
578.78
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Akt Inhibitor, The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Segment
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white to off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 5.0 µM for Akt (PKB)
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Use anhydrous DMSO for reconstitution.
Other Notes
Hu, Y., et al. 2000 J. Med. Chem.43, 3045.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
一体何が起きているの？
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable