126855
Alendronate, Sodium Salt
≥98% (NMR), farnesyl disphosphate synthase inhibitor, solid
別名:
Alendronate, Sodium Salt, Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
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この商品について
実験式（ヒル表記法）:
C4H12NNaO7P2 · 3H2O
CAS番号:
分子量:
325.12
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Alendronate, Sodium Salt, An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
Quality Segment
description
Merck USA index - 14, 229
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].[P](=O)([O-])(O)[C@@]([P](=O)(O)O)(O)CCCN.O.O.O
InChI
1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChI key
DCSBSVSZJRSITC-UHFFFAOYSA-M
General description
An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Farnesyl diphosphate synthase
Farnesyl diphosphate synthase
Product does not compete with ATP.
Reversible: no
Target IC50: 460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable