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126855

Alendronate, Sodium Salt

Name: Alendronate, Sodium Salt
Brand: MM

≥98% (NMR), farnesyl disphosphate synthase inhibitor, solid

別名:

Alendronate, Sodium Salt, Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate

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この商品について

実験式（ヒル表記法）:

C₄H₁₂NNaO₇P₂ · 3H₂O

CAS番号:

121268-17-5

分子量:

325.12

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD01748233

Assay:

≥98% (NMR)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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特性

製品名

Alendronate, Sodium Salt, An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

Quality Segment

100

description

Merck USA index - 14, 229

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].[P](=O)([O-])(O)[C@@]([P](=O)(O)O)(O)CCCN.O.O.O

InChI

1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1

InChI key

DCSBSVSZJRSITC-UHFFFAOYSA-M

詳細

General description

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC₅₀ = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC₅₀ = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC₅₀ = 40-70 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Farnesyl diphosphate synthase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.62, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys.373, 231.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

ピクトグラム

GHS07

注意喚起語

Warning

ハザードコード

H302

注意事項

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）