171264
AMPK Inhibitor, Compound C•2HCl
InSolution
別名:
InSolution AMPK Inhibitor, Compound C•2HCl, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O, AMPK Inhibitor I, AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O
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この商品について
実験式（ヒル表記法）:
C24H25N5O
CAS番号:
分子量:
399.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
liquid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
shipped in
ambient
storage temp.
−20°C
SMILES string
[n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3
InChI
1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChI key
XHBVYDAKJHETMP-UHFFFAOYSA-N
General description
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No.123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
Packaging
Packaged under inert gas
Physical form
A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
Preparation Note
Following intial thaw, aliquot and freeze (-20°C).
Other Notes
Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
12 - Non Combustible Liquids
wgk
WGK 2