197900
BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).
別名:
BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
実験式（ヒル表記法）:
C5H12BNO4S · xHCl
分子量:
193.03 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥97% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.
Biochem/physiol Actions
Cell permeable: no
Primary Target
arginase 1, arginase 2
arginase 1, arginase 2
Product does not compete with ATP.
Reversible: no
Target Ki: 310 nM for human recombinant type II arginase, pH 7.5
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.
Other Notes
Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.
Kim, N.N., et al. 2001. Biochemistry40, 2678.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
保管分類
11 - Combustible Solids
wgk
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Class I Designated Chemical Substances
prtr
197900-5MG: + 197900-5UNMG: + 197900-VMG:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。