200487
β-Amyloid Oligomer Inhibitor, K01-162
The β-Amyloid Oligomer Inhibitor, K01-162 controls the biological activity of β-Amyloid Oligomer.
別名:
β-Amyloid Oligomer Inhibitor, K01-162, AβO Inhibitor, K01-162
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この商品について
実験式（ヒル表記法）:
C15H14BrN
分子量:
288.18
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles, protect from light
color
white to off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
Packaging
Packaged under inert gas
Other Notes
Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable