203701
bpV(HOpic)
A potent phosphotyrosine phosphatase inhibitor.
別名:
bpV(HOpic), Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV
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この商品について
化学式:
K2[VO(O2)2C6H4NO3] · 4H2O
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥70% (51V-NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥70% (51V-NMR)
form
solid
potency
14 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
water: 4 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
PTEN
PTEN
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Unstable in solution; reconstitute just prior to use.
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable