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8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt

Name: 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Brand: MM

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

別名:

Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt, 8-Bromo-cGMP, Br-cGMP, Na

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この商品について

実験式（ヒル表記法）:

C₁₀H₁₀BrN₅O₇P · Na

CAS番号:

51116-01-9

分子量:

446.08

UNSPSC Code:

41106305

NACRES:

NA.77

MDL number:

MFCD00070128

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated

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特性

製品名

Guanosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt, Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4[nH]c(n[c](c4nc3Br)=O)N)CO1)O

InChI

1S/C10H11BrN5O7P/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18)/t2-,4-,5-,8-/m1/s1

InChI key

YUFCOOWNNHGGOD-UMMCILCDSA-N

詳細

General description

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
protein kinase G

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.

Other Notes

Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
Ruth, P., et al. 1991. Eur. J. Biochem.202, 1339.
Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem.56, 400.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c