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208293

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01

Name: Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01
Brand: MM

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

別名:

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I

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この商品について

実験式（ヒル表記法）:

C₁₈H₂₁NO₄S

CAS番号:

407587-33-1

分子量:

347.43

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD02919058

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 50 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

InChI key

ACLUEOBQFRYTQS-UHFFFAOYSA-N

詳細

General description

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC₅₀ = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC₅₀ = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).

Packaging

Packaged under inert gas

Other Notes

Fuente, R., et al. 2011, Mol Pharmacol.73, 758.
Namkung, W., et al. 2011, J Biol Chem.286, 2365.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c