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208724

Calpain Inhibitor IV

Name: Calpain Inhibitor IV
Brand: MM

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

別名:

Calpain Inhibitor IV, Z-LLY-FMK

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この商品について

実験式（ヒル表記法）:

C₃₀H₄₀FN₃O₆

分子量:

557.65

NACRES:

NA.77

UNSPSC Code:

12352200

eCl@ss:

32160702

Form:

solid

Storage condition:

OK to freeze, desiccated

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特性

Quality Segment

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white to pale yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

詳細

General description

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Cell permeable: yes

Primary Target
calpain 2

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Z-Leu-Leu-Tyr-CH₂F

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

WGK

WGK 1

引火点 (F)

Not applicable

引火点（°C）