主要文書

すべての文書を表示

215901

Carbonic Anhydrase IX/XII Inhibitor II, U-104

Name: Carbonic Anhydrase IX/XII Inhibitor II, U-104
Brand: MM

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

別名:

Carbonic Anhydrase IX/XII Inhibitor II, U-104, CAIX Inhibitor II

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₁₃H₁₂FN₃O₃S

分子量:

309.32

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00159265

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N

InChI key

YJQZNWPYLCNRLP-UHFFFAOYSA-N

詳細

General description

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

Packaging

Packaged under inert gas

Other Notes

Lock, F.E., et al. 2012. Oncogenein press.
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c