232120
cis-Diammineplatinum(II) dichloride
≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem
別名:
Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum
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この商品について
製品名
Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
Quality Segment
description
Merck USA index - 14, 2317
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
PBS with 140 mM NaCl: 1 mg/mL, water with 154 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
2-8°C
InChI
1S/2Cl.2H3N.Pt/h;;2*1H3;
InChI key
JFUARQHXOQHNLK-UHFFFAOYSA-N
General description
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
Biochem/physiol Actions
Induces apoptosis in cancer cells
Preparation Note
Other Notes
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
Legal Information
Disclaimer
注意喚起語
Danger
標的臓器
Respiratory system
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
引火点 (F)
Not applicable
引火点（°C）
Not applicable
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Substances Subject to be Indicated Names
ishl_indicated
Substances Subject to be Notified Names
ishl_notified
232120-50MG:
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