233183
Clodronate disodium Salt
≥97% (titration), bone resorption inhibitor, solid
別名:
Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
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この商品について
実験式（ヒル表記法）:
CH2Cl2Na2O6P2 · 4H2O
CAS番号:
分子量:
360.92
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (titration)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
製品名
Clodronate, Disodium Salt, A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.
Quality Segment
description
Merck USA index - 14, 2371
assay
≥97% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O
InChI
1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
InChI key
XWHPUCFOTRBMGS-UHFFFAOYSA-L
General description
A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Osteoclast-mediated bone resorption
Osteoclast-mediated bone resorption
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
Other Notes
Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
WGK
WGK 1
引火点 (F)
Not applicable
引火点（°C）
Not applicable