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235420

Caspase-3 Inhibitor I

Name: Caspase-3 Inhibitor I
Brand: MM

≥90% (HPLC), solid

別名:

Caspase-3 Inhibitor I, CPP32/Apopain Inhibitor, Ac-DEVD-CHO

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この商品について

実験式（ヒル表記法）:

C₂₀H₃₀N₄O₁₁

CAS番号:

169332-60-9

分子量:

502.47

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00671412

Assay:

≥90% (HPLC)

Form:

solid

Storage condition:

OK to freeze

テクニカルサービス

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特性

製品名

Caspase-3 Inhibitor I, The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Segment

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 5 mg/mL, water: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

InChI key

UMBVAPCONCILTL-MRHIQRDNSA-N

詳細

General description

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 200 pM against caspase-3

Packaging

Yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Asp-Glu-Val-Asp-CHO

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）