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264155

Caspase-3 Inhibitor II

Name: Caspase-3 Inhibitor II
Brand: MM

≥90% (TLC), irreversible CPP-32/apopain inhibitor, solid

別名:

Caspase-3 Inhibitor II, Z-D(OMe)E(Ome)VD(OMe)-FMK

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この商品について

実験式（ヒル表記法）:

C₃₀H₄₁FN₄O₁₂

CAS番号:

210344-95-9

分子量:

668.66

MDL number:

MFCD23380217

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥90% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated

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特性

製品名

Caspase-3 Inhibitor II, The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Segment

200

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white to slightly brown

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(=O)OC)CCC(=O)OC)C(C)C)CC(=O)OC

InChI

1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

InChI key

GBJVAVGBSGRRKN-JYEBCORGSA-N

詳細

General description

A potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-3, caspase-6, caspase-7, caspase-8, caspase-10

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature 376, 37.

Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 1

引火点 (F)

Not applicable

引火点（°C）