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3301

17β-Estradiol

Name: 17&#946;-Estradiol
Brand: MM

≥97% (HPLC), solid, estrogenic hormone, Calbiochem

別名:

17β-Estradiol, 17 beta Estradiol

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この商品について

実験式（ヒル表記法）:

C₁₈H₂₄O₂

CAS番号:

50-28-2

分子量:

272.38

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00003693

Assay:

≥97% (by assay)

Form:

solid

Storage condition:

OK to freeze

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特性

製品名

17β-Estradiol, Most potent mammalian estrogenic hormone.

Quality Segment

100

description

RTECS - KG2975000
Merck USA index - 14, 3703

assay

≥97% (by assay)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

O[C@@H]1[C@@]2([C@H]([C@H]3[C@H](CC2)c4c(cc(cc4)O)CC3)CC1)C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

詳細

General description

17β-Estradiol is a potent estrogen, a steroid hormone, involved in reproductive and endocrine functions in mammals. It binds to estrogen receptors (ERα and ERβ) to regulate gene expression, influencing reproductive functions such as the proliferation of the uterine endometrium, ovulation, and maintenance of pregnancy. Additionally, 17β-Estradiol is involved in modulating metabolic processes, including lipid metabolism and insulin sensitivity, and exerts neuroprotective effects in the central nervous system.

Application

17β-Estradiol has been used to treat primary rat cortical neurons, to investigate its effects on neuronal responses to interleukin (IL)-6 and soluble IL-6 receptor treatment. It has also been administered subcutaneously to ovariectomized female mice to investigate its effects on Crhr1 and Esr1 mRNA expression in the nucleus accumbens.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

pictograms

GHS08,GHS09

signalword

Danger

hcodes

H351,H360Fd,H362,H410,EUH380,EUH430

pcodes

P201 - P202 - P260 - P263 - P273 - P280 - P308 + P313 - P391 - P405 - P501

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c