主要文書

すべての文書を表示

341607

PD 173074

Name: PD 173074
Brand: MM

≥97% (HPLC), FGF and VEGF receptor inhibitor, solid

別名:

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074, 1- t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea, PD173074, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XX, 1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea, PD173074, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XX

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

実験式（ヒル表記法）:

C₂₈H₄₁N₇O₃

CAS番号:

219580-11-7

分子量:

523.67

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD08705327

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

製品名

FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074, The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N(CCCCNc1nc2nc(c(cc2cn1)c3cc(cc(c3)OC)OC)NC(=O)NC(C)(C)C)(CC)CC

InChI

1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)

InChI key

DXCUKNQANPLTEJ-UHFFFAOYSA-N

詳細

General description

A cell-permeable pyridopyrimidine compound that acts as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors (IC₅₀ = 21.5 nM for FGFR1). It inhibits PDGFR and c-Src only at much higher concentration (IC₅₀ = 17.6 µM, 19.8 µM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µM. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC₅₀<5 nM) and overexpressed VEGFR2 (IC₅₀<200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Koziczak, M., et al. 2004. Oncogene23, 3501.
Trudel, S., et al. 2004. Blood103, 3521.
Skaper, S.D., et al. 2000. J. Neurochem.75, 1520.
Mohammadi, M., et al. 1998. EMBO J.17, 5896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Still not finding the right product?

Explore all of our products under FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074

保管分類

11 - Combustible Solids

一体何が起きているの？

WGK 3

引火点 (F)

Not applicable

引火点（°C）