361554
TWS119
≥95% (HPLC), solid, GSK-3β inhibitor, Calbiochem®
別名:
GSK-3β Inhibitor XII, TWS119, Neurogenesis Inducer, TWS119
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この商品について
実験式（ヒル表記法）:
C18H14N4O2
CAS番号:
分子量:
318.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
製品名
GSK-3β Inhibitor XII, TWS119, The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Quality Segment
assay
≥95% (HPLC)
form
solid
potency
30 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
methanol: 2 mg/mL, DMSO: 200 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[nH]1c2nc(cc2c(nc1)Oc4cc(ccc4)O)c3cc(ccc3)N
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
General description
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biochem/physiol Actions
Cell permeable: yes
Kd = 126 nM against GSK-3β
Primary Target
GSK-3β
GSK-3β
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7632.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
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保管分類
11 - Combustible Solids
wgk
WGK 3