365251
Gö 6983
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.
別名:
Gö 6983, 2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
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この商品について
実験式（ヒル表記法）:
C26H26N4O3
CAS番号:
分子量:
442.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
製品名
Gö 6983, A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes.
SMILES string
N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)ccc(c3)OC
InChI
1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChI key
LLJJDLHGZUOMQP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange-red
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
関連するカテゴリー
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKCα and PKCβ
PKCα and PKCβ
Product competes with ATP.
Reversible: yes
Target IC50: 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
Disclaimer
Toxicity: Standard Handling (A)
General description
A potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
Other Notes
Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 3
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 365251-500UGCN | 04055977192032 |
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