369075
Guanidine Hydrochloride
ULTROL® Grade, ≥99% (titration), protein denaturant for purification of proteins, nucleic acids, and mRNA
別名:
Guanidinium chloride
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この商品について
実験式（ヒル表記法）:
CH5N3 · xHCl
CAS番号:
分子量:
59.07 (free base basis)
UNSPSC Code:
12352107
NACRES:
NA.25
MDL number:
description
Merck USA index - 14, 4562
Quality Segment
assay
≥99% (titration)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
ethanol: soluble, water: soluble
shipped in
ambient
storage temp.
15-25°C
SMILES string
[Cl-].[N+H3]\C(=N\[H])\N
InChI
1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChI key
PJJJBBJSCAKJQF-UHFFFAOYSA-N
General description
A powerful protein denaturant that is widely used in the purification of proteins, nucleic acids, and mRNA. It is used in a variety of applications, including sequencing, molecular weight determinations, and as a solubilizing agent for electrophoresis.
Absorbance (6.0 M, H2O): <0.2 at 230 nm; <0.03 at 260 nm.
Application
- Revealing the Roles of Guanidine Hydrochloride Ionic Liquid in Ion Inhibition and Defects Passivation for Efficient and Stable Perovskites Solar Cells: Discusses how guanidine hydrochloride ionic liquid enhances the efficiency and stability of perovskite solar cells by ion inhibition and defect passivation (Saeed A et al., 2024).
- N-Fluorosulfonyl Guanidine: An Entry to N-Guanyl Sulfamides and Sulfamates: Investigates the use of N-fluorosulfonyl guanidine for synthesizing N-guanyl sulfamides and sulfamates, showcasing its potential in chemical synthesis and material science (Wang W et al., 2024).
- Efficient extraction of lignin from moso bamboo by microwave-assisted ternary deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis: Explores the role of guanidine hydrochloride in enhancing the enzymatic hydrolysis of lignin extracted from moso bamboo using a microwave-assisted deep eutectic solvent method (Feng Y et al., 2024).
- Computational Enzyme Redesign Enhances Tolerance to Denaturants for Peptide C-Terminal Amidation: Details how computational redesign of enzymes, involving guanidine hydrochloride, can enhance their tolerance to denaturants, improving the efficiency of peptide C-terminal amidation processes (Zhu T et al., 2024).
- Parasite Burden of Trypanosoma cruzi in Whole Blood and Buffy Coat Determined by Real-Time PCR in Individuals with Chronic Chagas Disease: Describes the use of guanidine hydrochloride in real-time PCR processes to quantify the parasite burden in blood samples from individuals with Chagas disease, demonstrating its utility in enhancing diagnostic assays (Liempi D et al., 2024).
Other Notes
Bastiras, S., and Wallace, J.C. 1992. Biochemistry31, 9304.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.
Plaza del Pino, I.M., et al. 1992. Biochemistry31, 11196.
Steinman, H., et al. 1974. J. Biol. Chem.249, 7326.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Substances Subject to be Indicated Names
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Substances Subject to be Notified Names
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