382149
Histone Deacetylase Inhibitor III
The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
別名:
Histone Deacetylase Inhibitor III, M344, 4-Dimethylamino- N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide, M344, 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)benzamide, N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide
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この商品について
実験式（ヒル表記法）:
C16H25N3O3
CAS番号:
分子量:
307.39
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N(O)C(=O)CCCCCCNC(=O)c1ccc(cc1)N(C)C
InChI
1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
InChI key
MXWDSZWTBOCWBK-UHFFFAOYSA-N
General description
A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Rat liver HDAC
Rat liver HDAC
Product does not compete with ATP.
Reversible: no
Target IC50: 40 nM for rat liver HDAC
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753.
Jung, M., et al. 1999. J. Med. Chem.42, 4669.
Jung, M., et al. 1999. J. Med. Chem.42, 4669.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。